In the early Renaissance, the cultural heritage of classical authors influenced their readers to study plants. This influence and the valuable contribution of the invention of printing allowed botanical iconography and important herbariums of the sixteenth century, the study of the plant world took on a new impulse .
This brought about botanical gardens and above all, the Botanical Garden of Padua University, which still exists at the original site.
Founded in 1545 on the grounds of the Benedictine monks of Santa Giustina, it was instituted by a decree of the Senate of the Venetian Republic for the cultivation of 'simple' plants, that is medicine that was derived directly from nature, and since then, the Garden is a very active place of accumulation and synthesis of different disciplines. Art and architecture were just as important as the botanical criteria in the choice of plants to be cultivated.
It was Daniele Barbaro, a humanist and scholar of classical architecture, as well as a patron of Andrea Palladio, who designed the Garden as the little green universe. Its system has remained virtually intact to this day. This garden protected by high walls has always been used by the University for studying and teaching.